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    Researchers found out that participants using this drug for a year, dropped a few pounds within a month and have kept the body weight off through the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them far better and safer.

    Combo-pilling could be the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular is the fact that as of right now there aren't any long term prescription weightloss pills that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

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    Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed inside liver right after uptake from the intestines and possesses no therapeutic effect. Buprenorphine will be the active substance; it can be absorbed within the tongue (and throughout the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, the location where the first the main intestine is bypassed and the stomach contents empty into a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy in which the drug is taken up with the duodenum and transferred straight to the liver by the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken up by portions of the intestine which are not served through the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.